Division of Physiology

Personal Information

Michael C. Hogan, Ph.D.

Professor of Medicine

Department of Medicine,
University of California, San Diego
9500 Gilman Drive
La Jolla, CA 92093-0623
tel: (858)534-2773
fax: (858)534-4812
email: mchogan@ucsd.edu

Primary Interests

* Oxygen dependence of skeletal muscle function.
* Bioenergetics of contracting skeletal muscle.
* Mechanisms of fatigue in skeletal muscle.
* Photometric methods in cell physiology.
 
Isolated individual single skeletal muscle fiber.

Click image above for movie of fiber electrically stimulated to contract
(tetanic contractions at 0.3 Hz).

Education

University of Notre Dame, Indiana B.S. (Biology), 1976
University of Tennessee, Knoxville M.S. (Zoology), 1981
University of Tennessee, Knoxville Ph.D. (Physiology), 1985

Professional Experience

1985 - 1988 Postdoctoral Research Fellow, Department of Medicine, University of California, San Diego

Fondly Remembered, Casey Allen Kindig 1970-2004

kindig
1988 - 1990 Assistant Research Physiologist, Department of Medicine, University of California, San Diego
1990 - 1996 Assistant Adjunct Professor, Department of Medicine, University of California, San Diego
1996 - 2002 Associate Adjunct Professor, Department of Medicine, University of California, San Diego
2002 - present Professor, Department of Medicine, University of California, San Diego

Honors and Awards

1985 - 1988 NIH NRSA Post-doctoral Fellowship
1985 - 1988 Fellowship, American Lung Association of California.
1990 - 1992 Recipient of Parker B. Francis Foundation Research Fellowship.
1991 Recipient of American College of Sports Medicine Visiting Scholar Award.
1991 - 1996 NIH First Award
1993 Organizing Committee. Twenty-first annual meeting of the International
1993 – 1999 Society on Oxygen Transport to Tissue.
Associate Editor for Med. Sci. Sports Exer.
1996 - 2001 NIH R01
2000 - 2005 NIH PPG
2002 - 2007 NIH RO1
2008 - 2013 NIH RO1
Single fiber fluorescence workstation

Recent Selected Articles

  • Stary, C; Walsh, B; Knapp, A; Brafman, D; Hogan, MC. Elevation In Heat Shock Protein 72 mRNA Following Contractions In Isolated Single Skeletal Muscle Fibers. Am J Physiol Regul Integr Comp Physiol. In press, 2008.
  • Walsh B, Stary C, Howlett RA, Kelley KM, Hogan MC. Glycolytic activation at the onset of contractions in isolated single myofibers. Exp. Physiol. In press, 2008.
  • Zoladz J, Gladden B, Hogan MC, Nieckarz Z, Grassi B. Progressive recruitment of muscle fibers is not necessary for the slow component of VO2 kinetics. J Appl Physiol. In press, 2008.
  • Howlett RA, Kindig CD, Hogan MC. Intracellular PO2 kinetics at different contraction frequencies in Xenopus single skeletal muscle fibers. J Appl Physiol. 102: 1456-1461, 2007.
  • Howlett RA, Hogan MC. Effect of hypoxia on fatigue development in rat muscle composed of different fibre types. Exp Physiol. 92: 887-94, 2007.
  • Walsh B, Howlett RA, Stary CM, Kindig CA, Hogan MC. Measurement of activation energy and oxidative phosphorylation onset kinetics in isolated muscle fibers in the absence of crossbridge cycling. Am J Physiol Regul Integr Comp Physiol. 290: R1707-13, 2006.
  • Walsh B, Hooks RB, Hornyak JE, Koch LG, Britton SL, Hogan MC. Enhanced mitochondrial sensitivity to creatine in rats bred for high aerobic capacity. J Appl Physiol. 100: 1765-9, 2006.
  • Hogan MC. Vascular NO availability is an important determinant of impaired skeletal muscle microvascular PO2 in chronic heart failure. Acta Physiol 88:1 2006.
  • Gladden LB, Hogan MC. Lactic acid accumulation is an advantage/disadvantage during muscle activity. J Appl Physiol. 100:2100-1, 2006.
  • Stary CM, Hogan MC. Intracellular pH During Sequential, Fatiguing Contractile Periods In Isolated Single Xenopus Skeletal Muscle Fibers. J Appl Physiol. 99:308-12, 2005.
  • Grassi B, Hogan MC, Kelley KM, Howlett RA, Gladden LB. Effects of nitric oxide synthase inhibition by L-NAME on oxygen uptake kinetics in isolated canine muscle in situ. J Physiol. 568:1021-33, 2005.
  • Walsh B, Howlett RA, Stary CM, Kindig CA, Hogan MC. Determinants of oxidative phosphorylation onset kinetics in isolated myocytes. Med Sci Sports Exerc. 37: 1551-8, 2005.
  • Kindig CA, Walsh B, Howlett RA, Stary CM, Hogan MC. Relationship between Intracellular PO2 Recovery Kinetics and Fatigability in Isolated Single Frog Myocytes. J Appl Physiol. 98:2316-9, 2005.
  • Howlett RA, Kelley KM, Grassi B, Gladden LB, Hogan MC. Caffeine administration results in greater tension development in previously fatigued canine muscle in situ. Exp Physiol. 90:873-9, 2005.
  • Kindig CA, Stary CM, Hogan MC. Effect of dissociating cytosolic calcium and metabolic rate on intracellular PO2 kinetics in single frog myocytes. J Physiol. 562:527-34, 2005.
  • Kindig, CA, Howlett, RA, and Hogan, MC. Effect of contractile duration on intracellular PO2 kinetics in Xenopus single skeletal myocytes. J Appl Physiol. 98:1639-45, 2005.
  • Hogan MC, Stary CM, Balaban RS, Combs CA. NAD(P)H fluorescence imaging of mitochondrial metabolism in contracting Xenopus skeletal muscle fibers: effect of oxygen availability. J Appl Physiol 98:1420-6, 2005.
  • Kindig CA, Stary CM, Hogan MC. Effect of dissociating cytosolic calcium and metabolic rate on intracellular PO2 kinetics in single frog myocytes. J Physiol. 562:527-34, 2005.
  • Kindig C.A., Howlett R.A., Stary C.M., Walsh B., and Hogan M.C. Effects of acute creatine kinase inhibition on metabolism and contractility in isolated single myocytes. J Appl Physiol. 98:541-9, 2005.
  • Mason SD, Howlett RA, Kim MJ, Olfert IM, Hogan MC, McNulty W, Hickey RP, Wagner PD, Kahn CR, Giordano FJ, Johnson RS. Loss of skeletal muscle HIF-1α results in altered exercise endurance. PLoS Biol. 2:e288, 2004.
  • Stary, C.M., O. Mathieu-Costello and M.C. Hogan. Resistance to fatigue of individual Xenopus single skeletal muscle fibers is correlated with mitochondrial volume density. Exp Physiol. 89:617-21, 2004.
  • Haseler LJ, Kindig CA, Richardson RS, Hogan MC. The role of oxygen in determining phosphocreatine onset kinetics in exercising humans. J Physiol. 558:985-92, 2004.
  • Hogan, MC, B Grassi, M Samaja, CM Stary, LB Gladden. Effect of contraction frequency on the contractile and non-contractile phases of muscle venous blood flow. J Appl Physiol. 95(3):1139-44 2003.
  • Stary, CM, S Kohin, M Samaja, RA Howlett, MC Hogan. Trimetazidine reduces basal cytosolic Ca2+ concentration during hypoxia in single Xenopus skeletal myocytes. Exp Physiol. 88: :415-21, 2003.
  • Hepple, RT, CM Stary, S Kohin, PD Wagner, MC Hogan. No effect of trans sodium crocetinate on maximal O2 conductance or VO2max in moderate hypoxia. Respir Physiol Neurobiol. 134:239-46, 2003.
  • Kindig, CA, RA Howlett, and MC Hogan. Effect of extracellular PO2 on the fall in intracellular PO2 in contracting single myocytes. J. Appl. Physiol. 94:1964-70, 2003.
  • Howlett, RA, and MC Hogan. Dichloroacetate accelerates the fall in intracellular PO2 at onset of contractions in Xenopus single muscle fibers. Am J Physiol Regul Integr Comp Physiol. 284(2):R481-5, 2003.
  • Kindig, CA, KM Kelley, RA Howlett, CM Stary, and MC Hogan. Assessment of O2 uptake dynamics in isolated single skeletal myocytes. J Appl Physiol. 94: 353-7, 2003.
  • Grassi, B, MC Hogan, PL Greenhaff, JJ Hamann, KM Kelley, WG Aschenbach, D Constantin-Teodosiu, and LB Gladden. Oxygen uptake on-kinetics in dog gastrocnemius in situ following activation of pyruvate dehydrogenase by dichloroacetate. J Physiol. 538(Pt 1):195-207, 2002.
  • Howlett, RA, and MC Hogan. Intracellular PO2 decreases with increasing stimulation frequency in contracting single Xenopus muscle fibers. J Appl Physiol. 2: 632-6, 2001.
  • Kohin, S, CM Stary, RA Howlett, and MC Hogan. Preconditioning improves function and recovery of single muscle fibers during severe hypoxia and reoxygenation.  Am J Physiol Cell Physiol. 281: C142-6, 2001.
  • Hogan, MC. Fall in intracellular PO2 at the onset of contractions in Xenopus single skeletal muscle fibers. J Appl Physiol. 90:1871-6, 2001.
  • Howlett, RA, CM Stary, and MC Hogan. Recovery of force during postcontractile depression in single Xenopus muscle fibers. Am J Physiol Regul Integr Comp Physiol. 28: R1469-75, 2001.
  • Grassi, B, MC Hogan, KM Kelley, WG Aschenbach, JJ Hamann, RK Evans, RE Patillo, and LB Gladden. Role of convective O2 delivery in determining VO2 on-kinetics in canine muscle contracting at peak VO2. J Appl Physiol. 88: 1743-8, 2000.
  • Stary, C.M., and M.C. Hogan. Phosphorylating pathways and fatigue development in contracting Xenopus single skeletal muscle fibers. Am J. Physiol. Regulatory Integrative Comp. Physiol. 278: R587-R591, 2000.
  • Stary, C.M., and M.C. Hogan. Impairment of Ca2+ release in single Xenopus muscle fibers fatigued at varied extracellular PO2. J. Appl. Phsiol.  88: 1743-1748, 2000.